BDBM50002369 (2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid::(3S,4R)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-L-proline::CHEMBL275040::Digenin::Digensaeure::Helminal::Kainate::Kainsaeure::L-alpha-kainic acid::alpha-Kainic acid::digenic acid::kainic acid

SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI Key InChIKey=VLSMHEGGTFMBBZ-OOZYFLPDSA-N

Data  39 KI  2 IC50  1 Kd  24 EC50

PDB links: 45 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50002369   

TargetGlutamate receptor ionotropic, kainate 1(RAT)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  2.20nMMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  75.9nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  177nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  177nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataIC50:  77nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataEC50:  1.62E+4nMAssay Description:Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataEC50:  3.70E+4nMAssay Description:Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo...Checked by AuthorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataEC50:  1.62E+4nMAssay Description:Effective concentration against GluR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(RAT)
Suntory Institute For Bioorganic Research

Curated by PDSP Ki Database
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataEC50:  1.20E+4nMAssay Description:Compound was tested for agonistic activity on rat dorsal root ganglion neurons (thought to express GluR5 receptors)More data for this Ligand-Target Pair